The Biositemaps Protocol allows scientists, engineers, centers and institutions engaged in modeling, software tool development and analysis of biomedical and informatics data to broadcast and disseminate to the world the information about their latest computational biology resources (data, software tools and web-services). The biositemap concept is based on ideas from and Crawler-friendly Web Servers, and it integrates the features of Sitemaps and RSS feeds into a decentralized mechanism for announcing and communicating updates to existent and introduction of new biomedical data and computing resources. These site, institution or investigator specific biositemap descriptions are posted in XML format online and are searched, parsed, monitored and interpreted by web search engines, human and machine interfaces, custom-design web crawlers and other outlets interested in discovering updated or novel resources for bioinformatics and biomedical research investigations. The biositemap mechanism separates the providers of biomedical resources (investigators or institutions) from the consumers of resource content (researchers, clinicians, news media, funding agencies, educational and research initiatives). A Biositemap is an XML file that lists the biomedical and bioinformatics resources for a specific research group or consortium. It allows developers of biomedical resources to completely describe the functionality and usability and of each of their software tools, databases or web-services. Biositemaps are particularly beneficial in situations * when providers and consumers of bioinformatics and biomedical computing resources need to communicate in a scalable, efficient, agile and decentralized fashion. In these cases, a human (graphical) or a machine (computer) interface connects the descriptions of resources and facilities the search, comparison and utilization of most relevant resources for specific scientific studies. This infrastructure enables effective and timely matching of services and needs among biomedical investigators and the public in general. * where meta-resources, computational or digital libraries need to update their contents to reflect the current states of newly developed biomedical materials and resources using AJAX, JSON or WSDL protocols. Biositemaps supplement and do not replace the existing frameworks for dissemination of data, tools and services. By broadcasting a relevant and up-to-date Biositemap file on the web, investigators and institutions are only helping different engine's crawlers, machine interfaces and users dynamically acquire, interpret, process and utilize the most accurate information about the state of the resources disseminated by the developing group. Using this biositemap protocol does not guarantee that your resources will be included in search indexes nor does it influence the way that your tools are ranked or perceived by the community.