Plant- made pharmaceuticals are the result of a break through application of biotechnology to plants, to enable them to produce therapeutic proteins that could ultimately be used by the medical community to combat life-threatening diseases. In this process plants themselves become ?factories? that manufacture therapeutic proteins. Crops such as corn, rice, soy, etc. are genetically altered to yield proteins with purity and activity equivalent to those produced by other manufacturing systems. Plant-made pharmaceuticals differ from traditional commodity agriculture on many fronts. Plant-made pharmaceutical research does not represent a new wave of value added commodity agriculture .Advantages of this route include large-volume production capacity ,reduced capital requirements, and freedom from potential viral and animal protein contamination. Plant - made pharmaceuticals are going to bring very vast changes in the field of production of drugs. This will help to meet the day to day increasing demands for biotech drugs, to meet the patient population needs, without substantial and timely investment. Aside from the potential to increase the accessibility to biotech-based drugs, plant-made pharmaceutical technology offers a safe method to produce pharmaceutical proteins, avoiding the risk of propagating animal pathogens and contaminants.